British Hollywood stars Emma Thompson and Colin Firth have called on the Prime Minister to offer a safe haven to refugees fleeing the bloodshed in Syria.
Monty Python star Michael Palin and fashion designer Dame Vivienne Westwood have also signed a letter backing the Refugee Council's plea for the UK to open its doors in response to an international effort to provide shelter for 30,000 of the most vulnerable Syrians fleeing the civil war.
The celebrities, including Firth's wife Livia, artist Grayson Perry and actress Juliet Stevenson, say they are "ashamed" that the UK has not pledged any resettlement places.
The United Nations High Commissioner for Refugees (UNHCR) has urged Western countries to take in 30,000 Syrian refugees by the end of the year.
As well as backing the UNHCR plan, the letter calls on David Cameron t o make it possible for Syrians with a connection to the UK to be assisted to enter the country to join their families and communities.
The letter says: "International consensus is growing that we need to do more to help people fleeing the violence reach safety. UNHCR have called for western countries to take 30,000 of the most vulnerable and so far 18 countries have responded by pledging resettlement places for Syrian refugees.
"We're ashamed that Britain isn't one of them, especially because the world is a long way off reaching the 30,000 minimum target set by UNHCR.
"Now is the time to step forward and play our part in delivering a global solution so that those who are most vulnerable find safety outside of the region: women at risk of sexual violence; children who have been orphaned; people who simply will not survive in the conditions in the camps on Syria's borders.
"We've done it before, offering temporary resettlement places to Kosovan, Bosnian and Vietnamese people in their hour of greatest need. As the largest refugee group in the world and with winter approaching, this is the Syrian people's hour of need.
"On behalf of Syrians in the UK desperately anxious about the safety of their loved ones, we are asking you to help, as a father, as a humanitarian and as a world leader.
"Money is no longer enough. We must provide a safe haven to the most vulnerable."
Refugee Council chief executive Maurice Wren said: "The UK has a proud tradition of protecting refugees and offering safety to people in their hour of greatest need. For people fleeing Syria, that time is now. We simply must respond by providing safe haven to the most vulnerable people or they may not survive the bitter winter conditions.
"Syria and its surrounding countries face a human catastrophe of colossal proportions. If Syria's neighbours close their borders, the consequences will be disastrous. Western countries have a moral imperative to show solidarity with the countries bordering Syria by sharing the responsibility for protecting the most vulnerable people fleeing the violence.
"People's lives and the stability of the region could depend on it."
Foreign Secretary William Hague told MPs that between January and September last year the UK accepted 1,100 Syrian refugees for asylum "treating them on their individual merits, as we do people from other nations".
He stressed that the UK was providing aid to support vulnerable refugees in Syria and its neighbours, including 250,000 medical consultations within Syria and tens of thousands outside it.
Mr Hague said: "I hope that no one will say anything other than that the United Kingdom is among the most generous and big-hearted nations on earth on this.
"We are by some distance the second largest donor country in the world, helping hundreds of thousands of people with medical consultations in Syria, Jordan and Lebanon."