George Osborne will seek to highlight Government efforts to boost the economy in the north of England when he helps start work on a £20 million rail upgrade at Manchester Airport.
The Chancellor will insist growth will not be "concentrated in any one place" following a warning from cabinet colleague Vince Cable that London was " draining the life out of the rest of the country".
His visit comes ahead of next week's Wythenshawe and Sale East parliamentary by-election, where the Conservatives are battling not to be pushed into third place by the UK Independence Party.
The airport project is the first part of a £600 million Northern Hub project to electrify lines and upgrade the network in and around the city by 2019.
It is expected to increase passenger capacity by 44 million a year and create 20,000 jobs.
Mr Osborne will say: "The Government's long term plan is about securing a recovery for all parts of the country.
"Each part of this project, like the first work at Manchester Airport station that I've kicked off today, will help us build the infrastructure we need to compete in the global race.
"This investment will ensure growth is not concentrated in any one place by keeping Britain connected and creating thousands of local jobs, delivering a brighter economic future for the whole country."
Liberal Democrat Business Secretary Mr Cable has said the capital is "becoming a giant suction machine draining the life" from the rest of the country.