England winger Josh Charnley will be out for up to two months with a knee injury sustained in Wigan's Challenge Cup win over Dewsbury.
Charnley, who has topped the Super League try-scoring chart for each of the last two seasons, twisted his knee in the early stages of the Warriors' 58-6 win over the Rams.
"Josh is going to be out for six to eight weeks," said Warriors head coach Shaun Wane. "He doesn't need an operation but needs time off his legs. He's slightly twisted his knee but there's no ligament damage."
Dom Manfredi is set to deputise, starting with Friday's home game against London Broncos, who have yet to win a game in 2014, and Wane admits he is tempted to rest some of his senior players ahead of the Easter schedule.
"I'll pick a very competitive team," Wane said. "We've had a few tough games this year so, if I need to rest someone before the Good Friday game at St Helens, I will.
"I've not made my mind up yet."